If you're working with a commercial printer you should be working in CMYK. There is a completely different gamut of color available in CMYK and RGB, since they represent completely reciprocal color models (subtractive versus additive, reflective versus transmissive). It is not at all uncommon for a gorgeous image rendered in RGB to be flat and dull in CMYK.
Worry first about working in the correct color space for your target output device. Well, let me rephrase that. Worry first about profiling your monitor so that you can make effective use of Photoshop's soft proofing. Then be sure to work in the target color space. For more information, Google "photoshop color management." The subject is far too vast to be treated in a forum message. Or twelve. ;-) |